Coronavirus infection COVID-19
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
No minimum to 99 Years
Inclusion criteria
Inclusion criteria: Households are eligible if all members of the household or their legal guardians consent to participation and 1) are willing to complete diaries and questionnaires for the duration of follow-up, 2) are willing to, and capable of self-sampling nose-throat swabs, saliva (if applicable) and capillary blood samples by finger. If parents/caretakers of young children are reluctant to take a blood sample from their child, this is no reason for exclusion. For the substudy starting in November 2022 participants who have participated in the household study will be eligible for the substudy.
Exclusion criteria
Exclusion criteria: Patients or household members who are unable to consent, or do not wish to provide informed consent. Children, pregnant women and patients lacking capacity will be included. Those lacking capacity to consent for themselves will be identified and consent will be sought from an appropriate consultee. Households who do not have daily access to a smartphone or tablet with internet connection, will be excluded, as follow-up of households requires the use of an interactive diary App.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimate key transmission parameters of SARS-CoV-2 in Europe from observing within household virus spread and seroconversion of household members. o Household secondary attack rates o Transmission rate The secondary SARS-CoV-2 attack rate is defined as the number of secondary cases divided by the number of household members at risk (i.e. excluding the index case). Substudy: Incidence rate of reinfections of SARS-CoV-2 and risk factors associated with the incidence of SARS-CoV-2 reinfections (demographic, clinical, virological and immunological). | — |
Secondary
| Measure | Time frame |
|---|---|
| Infer from the data the following transmission parameters: o Incubation period o Generation time o Susceptibility and infectiousness of different types of individuals (e.g. age, gender, disease severity, type of symptoms, viral load) o Household (e.g. household size, living conditions, sanitary facilities, pets) and behavioral characteristics that influence transmission To characterize the views and experiences of households regarding perceptions, practices regarding infection control, and impacts of imposed isolation measures. Describe clinical characteristics of mild/moderate SARS-CoV-2 infections that are detected during household follow-up and managed in community/ambulatory care. Describe infection control practices and behaviors in affected households Determine seroconversion rates during follow-up and how this compares with virologically confirmed SARS-CoV-2 infections Understand the broader epidemiology of SARS-CoV-2 through studying asymptomatic individuals Substudy: Incidence rate of (co-)infections (such as influenza viruses and RSV). | — |
Countries
Netherlands
Outcome results
None listed