Oxidative skeletal muscle metabolism in chronic heart failure patients with and without iron deficiency

Oxidative skeletal muscle metabolism in chronic heart failure patients with and without iron deficiency - Oxidative exercise capacity in chronic HF with and without ID

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52482

Enrollment

Registered

2018-06-07

Start date

2021-10-05

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure iron deficiency

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For HFrEF patients: - Diagnosis of chronic HF of either ischemic or non-ischemic etiology; - Stable, evidence-based medical therapy for HF; - LVEF 40% measured 34 mL/m2 or left ventricular mass index >=115 g/m2 (for males) or >=95 g/m2 (for females) or E/e* >=13 or mean e* (septal and lateral) =125 pg/mL when in sinus rhythm; >300 pg/mL when in atrial fibrillation. Additional inclusion criterion for subjects with ID: - Iron deficiency, defined as TSAT

Exclusion criteria

Exclusion criteria: - Age 100 mg/day

Design outcomes

Primary

Measure	Time frame
Bulk change of quadriceps phosphocreatine and inorganic phosphate content during exercise, pH time course during exercise and kinetics of oxidative ATP and phosphocreatine (PCr) resynthesis post-exercise.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results