posttraumatic stress disorder
Conditions
Interventions
The study includes 4 different groups: 40mg atomoxetine + placebo, 20mg
hydrocortisone + placebo, 40mg atomoxetine + 20mg hydrocortisone, 2 placebo
tablets. Within each group, both tablets are taken
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers between 18 and 35 years Right-handed Normal uncorrected hearing Normal or corrected-to-normal vision
Exclusion criteria
Exclusion criteria: Current regular medication intake (including corticosteroids and adrenergic medication, monoamine oxidase inhibitors, CYP2D6 inhibitors such as SSRIs) Pregnancy Contraindications for MRI scanning (e.g. pacemaker, implanted metal, claustrophobia) Current or history of any psychiatric disorder Disorders of the autonomic system Cardiovascular or cerebrovascular conditions Hepatic insufficiency Renal insufficiency Glaucoma Current or history of pheochromocytoma Recreational drug-use Smoking Body mass index lower than 18 or higher than 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are measures of the autonomic nervous system (skin conductance response). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters are pupil dilation meausres, subjective (expectancy ratings) indices of fear learning and recall and extinction, item memory performance and neuronal activity and connectivity patterns (hippocampus, amygdala, neocortex). | — |
Countries
Netherlands
Outcome results
None listed