Predicting outcome of total knee replacement surgery in patients with knee osteoarthritis: a prospective study on the role of altered central pain processing and structural, functional, metabolic, inflammatory and psychological factors.

Predicting outcome of total knee replacement surgery in patients with knee osteoarthritis: a prospective study on the role of altered central pain processing and structural, functional, metabolic, inflammatory and psychological factors. - Predicting outcome of total knee replacement surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52469

Enrollment

Registered

2019-12-19

Start date

2021-06-04

Completion date

Unknown

Last updated

2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee replacement and total knee arthroplasty

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Knee osteoarthritis patients > 40 years awaiting total knee replacement surgery. Both men and women of all ethnic backgrounds are included.

Exclusion criteria

Exclusion criteria: Patients with a neurological disorder or systemic disease possibly impacting pain will be excluded.

Design outcomes

Primary

Measure	Time frame
The relation between altered CPP, structural, functional, metabolic and psychological assessments (presurgery) and the subscore 'satisfaction' of the new KSS questionnaire. The primary endpoint is at 1 year.	—

Secondary

Measure	Time frame
Central Pain Processing (CPP) To identify localized and widespread sensitization, Quantitative Sensory Testing (QST) along with the Central Sensitization Inventory (CSI) will be used. QST incorporates measuring pain pressure threshold (PPT), thermal hyperalgesia, temporal summation and conditioned pain modulation. Structural measurement knee A radiologist will determine the degree of osteoarthritis presurgical using a Kellgren and Lawrence scale. Functional measurements knee Maximal voluntary muscle strength (isometric knee flexion and extension) will be measured using a hand-held dynamometer. Proprioceptive accuracy will be assessed presurgical and postsurgical measuring the repositioning error during a knee joint position sense tests, using an inclinometer. Functionality will be measured using the 30 seconds chair stand test (30s-CST). Subjectitve knee function will be measured by the Knee Society Knee Scoring System Metabolic factors Patients* metabolic profile will be quantified by calculating the Body Mass Index (BMI) and measuring the body composition using Bioelectrical Impedance Analysis (BIA). In addition, a venous blood sample will be analysed with the A1C test or glycohemoglobin test (Clover A1C Analyser). This A1C test provides information about the average blood sugar (glucose) level in the past 3 months. Inflammatory factors Signs of inflammation will be evaluated by measuring C-Reactive Protein (CRP) levels in a blood sample. Psychological factors Pain catastrophizing (Pain Catastrophizing Scale), the presence of anxiety and depression (Hospital Anxiety and Depression scale) and illness perceptions (Illness Perception Questionnaire) will be measured using questionnaires.	—

Measure

Time frame

Central Pain Processing (CPP) To identify localized and widespread sensitization, Quantitative Sensory Testing (QST) along with the Central Sensitization Inventory (CSI) will be used. QST incorporates measuring pain pressure threshold (PPT), thermal hyperalgesia, temporal summation and conditioned pain modulation. Structural measurement knee A radiologist will determine the degree of osteoarthritis presurgical using a Kellgren and Lawrence scale. Functional measurements knee Maximal voluntary muscle strength (isometric knee flexion and extension) will be measured using a hand-held dynamometer. Proprioceptive accuracy will be assessed presurgical and postsurgical measuring the repositioning error during a knee joint position sense tests, using an inclinometer. Functionality will be measured using the 30 seconds chair stand test (30s-CST). Subjectitve knee function will be measured by the Knee Society Knee Scoring System Metabolic factors Patients* metabolic profile will be quantified by calculating the Body Mass Index (BMI) and measuring the body composition using Bioelectrical Impedance Analysis (BIA). In addition, a venous blood sample will be analysed with the A1C test or glycohemoglobin test (Clover A1C Analyser). This A1C test provides information about the average blood sugar (glucose) level in the past 3 months. Inflammatory factors Signs of inflammation will be evaluated by measuring C-Reactive Protein (CRP) levels in a blood sample. Psychological factors Pain catastrophizing (Pain Catastrophizing Scale), the presence of anxiety and depression (Hospital Anxiety and Depression scale) and illness perceptions (Illness Perception Questionnaire) will be measured using questionnaires.

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Countries

Netherlands

Outcome results