Pilot study to evaluate the potential value of Fluorescence In Situ Hybridization (FISH) of white blood cells for the diagnosis of Q fever fatigue syndrome

Pilot study to evaluate the potential value of Fluorescence In Situ Hybridization (FISH) of white blood cells for the diagnosis of Q fever fatigue syndrome - Evaluation of FISH as a diagnostic tool for Q fever fatigue syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52417

Enrollment

Registered

2020-09-14

Start date

2020-09-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q fever

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - At least 18 years old; - Able and willing to sign the informed consent form; - Known clinical Q fever history (absent for group A and B; Q fever fatigue syndrome for group C; proven chronic Q fever for group D); - Previous positive test for serological response to Coxiella burnetii (group B-D) and negative serological and cellular response to Coxiella burnetii for group A.

Exclusion criteria

Exclusion criteria: There are no specific criteria for subjects to be excluded from participation in this study, as long as they adhere to the inclusion criteria mentioned above.

Design outcomes

Primary

Measure	Time frame
Categorical FISH result (positive or negative, based on a pre-established cut-off of 5% positivity (3/50) among counted leukocytes).	—

Secondary

Measure	Time frame
Percentage of positively scored leukocytes per blood sample and fluorescent intensity of positively scored leukocytes.	—

Countries

Netherlands

Outcome results