orgaantransplantatie anti-donor immunity chronic kidney allograft rejection
Conditions
Interventions
A diagnostic kidney biopsy procedure will be performed and in addition an extra
biopsy will be taken for research purposes.
In addition, the patients will be asked to give 50 ml of heparin blood to
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -18 years and older -able to give informed consent -clinical diagnosis of chronic rejection for which a renal biopsy is indicated for confirmation
Exclusion criteria
Exclusion criteria: -known extra risk for bleeding (e.g. clotting disorder or medication)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters will be the number and characterization of intrarenal T cells in cases of chronic kidney allograft rejection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intrarenal T cells isolated from cases with chronic rejection will be compared to those isolated from individuals with chronic interstitial fibrosis without evidence for rejection. | — |
Countries
Netherlands
Outcome results
None listed