Relationship between regulation of peripheral and intracoronary microvascular blood flow in patients with ischemia and no obstructive coronary arteries

Relationship between regulation of peripheral and intracoronary microvascular blood flow in patients with ischemia and no obstructive coronary arteries - PERIPHERAL-FLOW

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52365

Enrollment

109

Registered

2021-12-22

Start date

2022-01-03

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary microvascular dysfunction Endothelial function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Clinical indication for elective ICFT - Persistent angina defined as symptoms of angina at least 2 times a month for the last 3 months - Absence of obstructive CAD diagnosed by CCTA and/or CAG. - Being able to speak and understand the Dutch or English language - Signed informed consent

Exclusion criteria

Exclusion criteria: - Under 18 years of age.

Design outcomes

Primary

Measure	Time frame
The main study end point is the difference in peripheral endothelial function between INOCA and HFpEF patients with and without CED measured with ICFT.	—

Secondary

Measure	Time frame
1) The relationship between microvascular reactivity measured using EndoPAT and LASCA in patients with INOCA and HFpEF. 2) The difference in peripheral endothelial function measured with LASCA between INOCA and HFpEF patients with and without an abnormal CFR and HMR measured with ICFT	—

Countries

Netherlands

Outcome results