High blood pressure
Conditions
Interventions
Perindopril or losartan use is stopped for 2 weeks to measure baseline blood
pressure without medication. With this the effect of de blood lowering drugs is
measured in a real-life population. Both
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Use of oral perindopril 2, 4 or 8 mg a day or losartan 25, 50 or 100 mg a day or in case of healthy controls willingness to use perindopril 4 mg or losartan 50 mg for five days - Age between 18-50 years or > 70 years - Providing informed consent after reading the patient information - Stopping is in accordance with the treating physician
Exclusion criteria
Exclusion criteria: • Not providing informed consent or not capable of giving informed consent, • End-stage renal disease (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary objective is to determine if there is a difference in exposure to losartan and perindopril measured with the (AUC) when comparing elderly (>70 years) with younger patients ( | — |
Secondary
| Measure | Time frame |
|---|---|
| We want to determine if there is a difference in the drop of blood pressure between older (>70 years) and younger ( | — |
Countries
Netherlands
Outcome results
None listed