MeaSuring free radicals with diamond magnetometRy In hUman single Sperm cells related to microbiota and lifestyle factors: SIRIUS study

MeaSuring free radicals with diamond magnetometRy In hUman single Sperm cells related to microbiota and lifestyle factors: SIRIUS study - SIRIUS study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52347

Enrollment

Registered

2021-11-17

Start date

2024-07-03

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

male infertility

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Males of couples visiting the CRM at the UMCG between 18-55 years old. • Planned semen-analysis as standard care.

Exclusion criteria

Exclusion criteria: * Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone suppletion and/or anabolic steroids * Males who are azoospermic * Males who have an abnormal SA due to genetic causes. * Semen analysis with round cells >2x106 /ml (as marker for infection) * Males who currently use antibiotics

Design outcomes

Primary

Measure	Time frame
The main study parameters will be free radical concentration in seminal plasma and at sperm cells correlated with microbiota in semen plasma and related to standard semen-parameters, malondialdehyde (MDA) en free thiols in bloof serum lifestyle factors and food intake.	—

Secondary

Measure	Time frame
na.	—

Countries

Netherlands

Outcome results