cognitief functioneren cognitive functioning
Conditions
Interventions
The intervention product is a nutritional supplement, composed of vitamins B2,
B3, B6, B9, C and D3. These vitamins will be delivered in the colon where most
of these vitamins can be utilized by the
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Healthy men and women * Aged between 18-50 years old * Participating in military field exercise * BMI between 18.5 - 30 kg/m2 * Stable body weight (
Exclusion criteria
Exclusion criteria: • Food allergies or other issues with foods that would preclude intake of the study products • History of gastro-intestinal surgery or gastro-intestinal complaints or gastrointestinal diseases (i.e., diarrhoea, Crohn's disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers) • Suffering from metabolic, neuro-psychiatric disease (i.e., diabetes, hepatitis, HIV, cancer, epilepsy, major depression, AD(H)D, schizophrenia, etc.) • Taking medication related to gut diseases or stress • Being severely immunocompromised (HIV positive, transplant patient, on antirejection medications, on a steroid for >30 days, or chemotherapy or radiotherapy within the last year); • Use of antibiotics within the previous 3 months • Not willing to refrain from taking other supplements during the intervention period • Pregnant, lactating or having a wish to become pregnant during the study • History of drug and/or alcohol abuse at the time of enrolment • Using doctor described drugs related to gut or neurological/psychiatric diseases • Alcohol intake > 3 servings of alcoholic beverages per day • Planned major changes in lifestyle (i.e. diet, dieting, exercise level, travelling) during the duration of the study • Suffering from an eating disorder • Vegetarian/vegan diet or other issues with foods that would preclude intake of the study products • High fibre diet (i.e. >30 g) based on our fibre intake screening tool; • Receiving treatment involving experimental drugs. If the subject has been in a recent experimental trial, these must have been completed not less than 60 days prior to this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcome is the backward digit span (DS) score, during the field exercise as compared to the start of the 6-week supplementation period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are other cognitive test scores and a combined (z-scored) cognitive performance score. Stress levels will be measured in salivary cortisol and self-perceived stress levels will be derived from the HADS and PSS-10 questionnaire. Other stress biomarkers (e.g. heart rate variability) will be measured by a wearable. | — |
Countries
Netherlands
Outcome results
None listed