diabetes
Conditions
Interventions
4 weeks of moderate-intensity cycle exercise training on a cycle ergometer in
the laboratory. Sessions will consist of 3 x 30 minutes exercise in week 1, 3 x
40 minutes exercise in week 2, 3 x 50 mi
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, participants with T1DM must meet all of the following criteria: • Individuals with T1DM with a diagnosed disease duration of 1 - 45 years • Male or female • Aged between 18-65 years In order to be eligible to participate in this study, healthy control participants must meet all of the following criteria: • No chronic health conditions and between the ages of 18-65
Exclusion criteria
Exclusion criteria: • History of asthma, stroke, chronic obstructive pulmonary disease, congestive heart failure, heart surgery, or congenital heart diseases • Current treatment with drugs known to interfere with metabolism e.g. systemic corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists • Are current smokers or have been a regular smoker within the last 12 months • Insulin pump therapy • Symptomatic autonomic or distal neuropathy • BMI >30 due to adiposity, since this is known to cause difficulties in obtaining muscle biopsies. • Pregnancy • Recent acute myocardial infarction (150 mmHg and Diastolic Blood Pressure > 100 mmHg on repeated measurements) • Active infection, anaemia, severe renal dysfunction (estimated Glomerular filtration rate 6 alcohol units per day or >14 alcohol units per week • Use of anticoagulants or anti platelet therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters: The differences in markers of insulin-independent glucose uptake, parameters of mitochondrial function and exercise tolerance between T1DM and control groups both before and after the exercise training intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Study Parameters: The differences in exercise tolerance and aerobic function parameters between T1DM and control groups before and after the exercise training intervention, and their relationships with markers of mitochondrial function. | — |
Countries
Netherlands
Outcome results
None listed