Sensitization in hand OsteoArthritis pain

Sensitization in hand OsteoArthritis pain - SensOA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52315

Enrollment

132

Registered

2022-02-02

Start date

2022-04-04

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand Osteoarthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 18-80 - Hand osteoarthritis according to the ACR criteria - Hand pain of at least 30mm on a 100mm VAS - Chronic hand pain

Exclusion criteria

Exclusion criteria: Part 1: - Known inflammatory rheumatic diseases - Psoriasis - Seropositivity for rheumatoid factor of anti-CCP antibodies - No understanding of the Dutch language Part 2: - Fibromyalgia (Following the ACR 2011 classification criteria) - Neurologic disorders interfering with the measurements or pain perception - Carpal tunnel syndrome interfering with the measurements or pain perception(i.e. bilateral CTS) - History of chemo- and/or radiotherapy - Spinal surgery or spinal trauma with lasting complaints interfering with the measurements or pain perception - Cognitive impairment or psychiatric disorders interfering with the measurements or pain perception - Pregnancy or breast-feeding - Eye surgery for glaucoma or keratoconus, or other surgery of the cornea in the three preceding months - Presence of an implantable cardioverter-defibrillator (ICD), neurostimulator or pacemaker

Design outcomes

Primary

Measure	Time frame
The main outcome will be pain phenotypes for patients with hand OA.	—

Secondary

Measure	Time frame
- Determinants of sensitization and neuropathic pain symptoms in the patients with hand OA - Prevalence of fibromyalgia as measured by the ACR 2011 classification criteria - Determinants of fibromyalgia in patients with hand OA - Prevalence of generalized small fiber pathology as measured by QST and CCM - Determinants of generalized small fiber pathology in patients with hand OA - Validity of the simplified QST test set as a screening tool for neuropathic pain symptoms compared to the comprehensive QST - Validity of the painDETECT questionnaire as a screening tool for neuropathic pain symptoms compared to the comprehensive QST - Association between severity of inflammation on ultrasonography of the hand joints and central sensitization and small fiber pathology - Association between serum (ARGS, HsCRP, CPRm, VICM) and urine (uCTX2) biomarkers and central sensitization and small fiber pathology.	—

Measure

Time frame

- Determinants of sensitization and neuropathic pain symptoms in the patients with hand OA - Prevalence of fibromyalgia as measured by the ACR 2011 classification criteria - Determinants of fibromyalgia in patients with hand OA - Prevalence of generalized small fiber pathology as measured by QST and CCM - Determinants of generalized small fiber pathology in patients with hand OA - Validity of the simplified QST test set as a screening tool for neuropathic pain symptoms compared to the comprehensive QST - Validity of the painDETECT questionnaire as a screening tool for neuropathic pain symptoms compared to the comprehensive QST - Association between severity of inflammation on ultrasonography of the hand joints and central sensitization and small fiber pathology - Association between serum (ARGS, HsCRP, CPRm, VICM) and urine (uCTX2) biomarkers and central sensitization and small fiber pathology.

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Countries

Netherlands

Outcome results