Leiden Longevity Study follow-up study

Leiden Longevity Study follow-up study - LLS follow-up study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52307

Enrollment

500

Registered

2021-08-30

Start date

2021-11-01

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

veroudering, cardio-metabole gezondheid, darmgezondheid, cognitie en leeftijdsgerelateerde ziektes ageing healthy ageing

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Participated in the first wave of the Leiden Longevity Study in 2002, with at least a baseline blood sample present and preferably participated in the third round of the LLS in 2009-2010, or in at least one other follow-up study of the LLS - Able to give written informed consent - Willing and able to visit the research centre in Leiden with public or private transport - Willing and able to follow the study protocol

Exclusion criteria

Exclusion criteria: - Not able to give written informed consent - Not able to visit the research center in Leiden with public or private transport - Not able to follow the study protocol

Design outcomes

Primary

Measure	Time frame
We will investigate changes in cardio-metabolic, cognitive, and physical performance over time and obtain novel biomarker in this follow up study. Phenotypic characteristics to be collected: Cardio-metabolic measurements o (1H NMR based) Nightingale metabolomics o Blood pressure o Body composition (Bioelectrical impedance analysis (BIA)) o Heart rate and heart rate variability (Electrocardiogram (ECG) (novel at follow-up)) Cognitive function o Attention (Stroop colour word test) o Processing speed (Digit Symbol Substitution Test (DSST)) o Memory (15-Picture learning test (PWL)) o Global cognitive function (Mini-Mental State Examination (MMSE) (novel at follow-up)) o Language (Animal fluency (novel at follow-up)) o Subjective memory complaints (novel at follow-up) Physical performance o Hand grip strength o Short Physical Performance Battery (SPPB) o Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) questionnaires (novel at follow-up) Gut health (novel at follow-up): o Stool sample to perform gut microbiome 16S measurements o Questionnaire on stool sample and Bristol Stool Chart o Gastrointestinal symptom rating scale (GSRS) questionnaire Habitual dietary intake o Food Frequency Questionnaire (FFQ) Physical activity o Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH) (novel at follow-up) Anthropometric measurements o Heigth o Weight o Hip and waist circumference Mood, depression, apathy, and quality of life o Several general questions on well-being o Center for Epidemiological Studies Depression Scale (CES-D) o EuroQol five dimensions questionnaire (EQ-5D-3L) (novel at follow-up) o EQ-VAS (novel at follow-up) Medication use o List from pharmacy o Check of the pharmacy list with participant Medical history o List from GP o Check of the GP list with participant General questionnaire on marital status, occupation, education, alcohol use, smoking, self-rated health, a	—

Measure

Time frame

We will investigate changes in cardio-metabolic, cognitive, and physical performance over time and obtain novel biomarker in this follow up study. Phenotypic characteristics to be collected: Cardio-metabolic measurements o (1H NMR based) Nightingale metabolomics o Blood pressure o Body composition (Bioelectrical impedance analysis (BIA)) o Heart rate and heart rate variability (Electrocardiogram (ECG) (novel at follow-up)) Cognitive function o Attention (Stroop colour word test) o Processing speed (Digit Symbol Substitution Test (DSST)) o Memory (15-Picture learning test (PWL)) o Global cognitive function (Mini-Mental State Examination (MMSE) (novel at follow-up)) o Language (Animal fluency (novel at follow-up)) o Subjective memory complaints (novel at follow-up) Physical performance o Hand grip strength o Short Physical Performance Battery (SPPB) o Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) questionnaires (novel at follow-up) Gut health (novel at follow-up): o Stool sample to perform gut microbiome 16S measurements o Questionnaire on stool sample and Bristol Stool Chart o Gastrointestinal symptom rating scale (GSRS) questionnaire Habitual dietary intake o Food Frequency Questionnaire (FFQ) Physical activity o Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH) (novel at follow-up) Anthropometric measurements o Heigth o Weight o Hip and waist circumference Mood, depression, apathy, and quality of life o Several general questions on well-being o Center for Epidemiological Studies Depression Scale (CES-D) o EuroQol five dimensions questionnaire (EQ-5D-3L) (novel at follow-up) o EQ-VAS (novel at follow-up) Medication use o List from pharmacy o Check of the pharmacy list with participant Medical history o List from GP o Check of the GP list with participant General questionnaire on marital status, occupation, education, alcohol use, smoking, self-rated health, a

—

Countries

Netherlands

Outcome results