persistent genital arousal syndrome
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Adult, >18 years of age - Able to give written informed consent In addition, for PGAS patients: - Diagnosed with PGAS, defined by the following criteria: i. Involuntary genital and clitoral arousal that persists for an extended period of time (hours, days, months); ii. The physical genital arousal does not go away following one or more orgasms; iii. The genital arousal is unrelated to subjective feelings of sexual desire; iv. The persistent feelings of genital arousal feel intrusive and unwanted; and v. Feelings of distress. In addition, for healthy controls: - Not diagnosed with a pain syndrome - Reporting an average daily pain score of NRS
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: PGAS patients and healthy controls: - Regular use of opioids (>3 of 7 days per week) - Inability to undergo quantitative sensory testing in the genital region (for whatever reason, as judged by the subject or investigator)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the description of sensory testing abnormalities in the genital region in PGAS patients and healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine if sensory abnormalities in PGAS patients are isolated to the genital region or show a generalized distribution 2. To assess if PGAS is associated with central sensitization 3. To correlate PGAS symptoms to psychological characteristics 4. To compare psychophysical characteristics between PGAS patients and healthy controls 5. To relate the severity of PGAS symptoms to outcomes in psychophysical evaluation | — |
Countries
Netherlands
Outcome results
None listed