Reperfusion of the brain after endovascular thrombectomy for ischemic stroke: development of novel prognostic imaging biomarkers using magnetic resonance imaging

Reperfusion of the brain after endovascular thrombectomy for ischemic stroke: development of novel prognostic imaging biomarkers using magnetic resonance imaging - Reperfuse

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52283

Enrollment

Registered

2022-02-03

Start date

2023-03-01

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral infarction stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - A clinical diagnosis of acute ischemic stroke - Age 18 years or older - Treated with EVT for a large vessel occlusion of the anterior circulation (intracranial carotid artery or middle cerebral artery (M1 segment or M2 segment) confirmed by neuroimaging (CTA or MRA) resulting in a successful recanalization (defined as eTICI >= 2B) - Written informed consent obtained

Exclusion criteria

Exclusion criteria: - Pre-stroke disability which interferes with assessment of functional outcome at 90 days, i.e. mRS >2 - Contraindication(s) for MRI (e.g. claustrophobia, pacemaker, metallic implant, known contrast allergy) - Clinical condition unsuited for MRI imaging or prolonged stay at the Radiology department (e.g. agitation and restlessness, neurologic deterioration) - Use of general anesthesia during EVT

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is the National Institutes of Health Stroke Scale (NIHSS) 24 hours after successful recanalization.	—

Secondary

Measure	Time frame
Secondary radiological outcomes at 24 hours after successful recanalization: - infarct volume on DWI/FLAIR - intracerebral haemorrhage according to the Heidelberg Bleeding Classification10 on SWI - recanalization status on MRA Secondary clinical outcomes: - Modified Rankin Scale (mRS) score at 90 days (± 14 days) - symptomatic intracranial haemorrhage (defined as haemorrhage detected on brain imaging with >=4 points increase in NIHSS)	—

Measure

Time frame

Secondary radiological outcomes at 24 hours after successful recanalization: - infarct volume on DWI/FLAIR - intracerebral haemorrhage according to the Heidelberg Bleeding Classification10 on SWI - recanalization status on MRA Secondary clinical outcomes: - Modified Rankin Scale (mRS) score at 90 days (± 14 days) - symptomatic intracranial haemorrhage (defined as haemorrhage detected on brain imaging with >=4 points increase in NIHSS)

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Countries

Netherlands

Outcome results