physical fitness performance physical fitness
Conditions
Interventions
12-week supplementation with 650 mg sweet orange and pomgranate extract (2
capsules per day) compared to placebo (760 mg maltodextrin).
Sponsors
Faculty of health, medicine and life sciences
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Healthy male/female (based on medical history provided during a general health questionnaire) - Age between 40 - 65 yrs - Overweight (BMI >=25 to
Exclusion criteria
Exclusion criteria: - Allergy to test product/control or citrus fruits and pomegranate - Medical conditions that might interfere with endpoints or compromise participant safety during testing (e.g. Cardiovascular diseases, cancer, Parkinson*s disease, Gastrointestinal diseases or abdominal surgery) to be decided by the principal investigator - Use of medication that might interfere with endpoints (i.e.: β-blockers, antioxidant, antidepressants.) - High fasting blood glucose (FBG >=126 mg/dL) - Recent skeletal muscle injury in less than one month before the start of the study - Use of antibiotics within 3 months prior Visit 2 - Use of probiotics or supplements containing vitamins, minerals or antioxidants four weeks prior to Visit 2 - Regular smoking (including use of e-cigarettes) - Inability to correctly perform the PA test during screening/familiarization - Abuse of alcohol (alcohol consumption >20 units/week) and/or drugs - Plans to change diet or medication for the duration of the study - Treatment with an investigational drug (phase 1-3) 180 days before the start of the study - Inability to understand study information and/or communicate with staff
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in aerobic capacity (VO2max), assessed with an Eklom-Bak submaximal cycling test. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Daily physical activity as determined by accelerometer - Dietary intake as measured by a 3-day food record - Muscle strength as measured by Handgrip strength - Muscle cell proliferation and differentiation and mitochondrial biogenesis assessed in skeletal muscle biopsies - Quality of Life as measured by the WHO-QOL-100 questionnaire - General health as measured by SF-36 questionnaire - Vitality as measured by the Dutch Vitality Questionnaire (Vita-16) - Cardiometabolic health biomarkers, cortisol, C-reactive protein determined with ELISA - Antioxidative capacity measured with a Trolox equivalent antioxidant capacity (TEAC) assay | — |
Countries
Netherlands
Outcome results
None listed