Duchenne Muscular Dystrophy / Duchenne
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Group A: DMD patients, MRI and NPE Group B: controls, MRI and NPE Group C: DMD patients, NPE For group A/C: Able to provide written informed consent Age 18 years or older Genetically confirmed diagnosis for DMD Male For group B: Able to provide written informed consent Age: maximally one year apart from a DMD participant (expected to be between 18-30 years old) Male
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study in group A: - MRI contraindications - Inability to complete the NPE A potential subject who meets any of the following criteria will be excluded from participation in this study in group B: - A diagnosis for any neurological or neuropsychological disorder - MRI contraindications - Inability to complete the NPE A potential subject who meets any of the following criteria will be excluded from participation in this study in group C: - Inability to complete the NPE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: Presence or absence or significant differences in brain volumes structural connectivity, cerebral perfusion and functional connectivity between patients and healthy controls with respect to age, after applying the appropriate statistics per measure. Neurocognitive parameters and behavioural functioning will be assessed to describe the cohorts. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed