neuroplasticiteit, slaap en gemoedstoestand sleep and mood
Conditions
Interventions
All participants will undergo four conditions. Each condition includes three
occasions of administering LSD (20 µg) or placebo in the morning, or in the
evening. The three dosing days within one con
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Written Informed Consent • Understanding the procedures and the risks associated with the study. • At least 18 years of age • Absence of any major medical condition as determined by medical examination and laboratory analysis • Absence of any major psychological condition as determined by medical examination • Free from psychotropic medication • Participants must be willing to refrain from taking illicit psychoactive substances during the study. • Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. • Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. • Participants are asked to not make any substantial changes in their diet. • Participants must be willing to comply with guidelines regarding their bedtime. • Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: • History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) • Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) • Pregnancy or lactation • Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg) • Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) • Psychotic disorder in first-degree relatives • Any chronic or acute medical condition • History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*) • For women: no use of a reliable contraceptive • Tobacco smoking (>20 per day) • Excessive drinking (>20 alcoholic consumptions per week) • Experience with a full dose of a psychedelic within the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective is to investigate the effects of three repeated morning vs evening doses of LSD (20 µg) on mood (self-rated). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are to investigate the effects of three repeated morning vs evening doses of LSD (20 µg) on [1] neuroplasticity (BDNF levels in blood samples), [2] sleep parameters, [3] cognitive performance measures of different memory types, [4] emotional attention, [5] emotion regulation [6] markers of well-being (cytokines in blood samples and self-rated questionnaire). Tertiary objectives are to investigate the effects of three repeated morning vs evening doses of LSD (20 µg) on [1] cortisol levels (blood samples), and [2] endocannabinoid concentrations (blood samples). | — |
Countries
Netherlands
Outcome results
None listed