humoral rejection
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - >=18 years old - About to receive a deceased donor or living donor renal transplant - Provide informed consent - Immunological high risk for rejection a. Luminex positive DSAs (Immucor background corrected MFI >500)8; and/or b. Re-transplantation with repeated mismatch; and/or c. Husband to wife donation (after fathering children); and/or d. Offspring to mother donation The healthy subjects are the living donors of aforementioned patients, they have to meet the following criteria, - >=18 years old - About to donate a kidney as a living donor - Provide informed consent
Exclusion criteria
Exclusion criteria: A potential subject who meets the following criterium will be excluded from participation in this study: - Regular follow-up after transplantation is not feasible - AB0-incompatible or HLA-incompatible kidney transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoints are the incidence of ABMR, the incidence of mixed ABMR/TCMR, and kidney function after at least one year of follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, the immune system will be mapped with a focus on B cell function, the development of (non-)HLA antibodies, the interaction between B cells and T follicular helper cells, and complete immune phenotypic profiling. | — |
Countries
Netherlands
Outcome results
None listed