cognitive functioning brain health
Conditions
Interventions
The FINGER-NL multidomain lifestyle intervention comprises eight domains,
namely 1) physical activity, 2) cognitive training, 3) cardiovascular risk
factor management, 4) dietary counselling, 5) Sou
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 60-79 years of age at pre-screening; - Adequate fluency in Dutch to understand the informed consent and complete (online) questionnaires ; - Providing informed consent to all study procedures; - Internet access at home - >=3 (self-reported) risk factors (must contain at least 2 modifiable risk factors and 1 non-modifiable risk factor): Modifiable risk factors: - Physical inactivity (1) - Unhealthy diet (1) - Low mental/cognitive activity (1) - High blood pressure (1) - High cholesterol (1) - High body mass index (BMI) (2) Non-modifiable risk factors: - First-degree family history of dementia - Subjective cognitive decline/memory complaints (1) Measured using LIBRA questionnaire; (2) Defined as >=25 kg/m2 for 60-69 years old, and >=28 kg/m2 for >=70 years old, based on self-reported height and weight.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of dementia or mild cognitive impairment at baseline (self-reported); 2. Significant cognitive impairment assessed using a validated telephone-administered cognitive battery (TICSm score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year change from baseline in global cognitive composite score derived from subtest scores from the Neuropsychological Test Battery (NTB) that includes 15-Word Verbal Learning Test delayed recall, DDST 90 seconds, WAIS digit span backwards, and semantic fluency. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints 2-year change from baseline in: a) individual cognitive test performances, representing memory (15-Word Verbal Learning Test delayed recall), processing speed (Digit Symbol Substitution Test 90 seconds) and attention and executive functioning (WAIS digit span backwards, semantic fluency); b) Instrumental activities of daily living using the Amsterdam Instrumental Activity of Daily Living Questionnaire (A-IADL-Q); c) Quality of life using the 5-level EuroQol-5D (EQ-5D-5L); d) Modifiable dementia risk using LIfestyle for BRAin health (LIBRA); e) Intervention specific outcomes: • Physical activity: grip strength, physical activity (SQUASH questionnaire), sedentary behavior (LASA Sedentary Behavior Questionnaire) and sarcopenia (SARC-F Sarcopenia Questionnaire. For participants at UMCG only: a physical activity diary (Physical Activity Record) • Cognitive training: cognitive function (semantic fluency test), metamemory (Metamemory in Adulthood Questionnaire); • Cardiovascular: blood pressure, cholesterol (total, HDL, LDL + triglycerides), blood glucose (HbA1C), medication adherence (Hill-Bone Medication Adherence Scale); • Dietary counselling: nutritional intake (Traqq app), adherence to Dutch dietary guidelines (Dutch healthy diet index); • Sleep counselling: sleep behavior (7 day sleep diary), insomnia (Insomnia severity index); • Stress management: mindfulness (Five Facet Mindfulness Questionnaire), perception of stress (Perceived Stress Scale); • Social activities: perceived social support (Lubben Social Network Scale), emotional and social loneliness (De Jong Gierveld Loneliness Scale). f) Blood-based biomarkers for Alzheimer*s disease (Aβ42/40, p-tau), axonal damage (NfL), astrocytes activity/injury or stress (GFAP) and brain plasticity (BDNF). | — |
Countries
Netherlands
Contacts
Public ContactM.D. Zwan
Amsterdam UMC
Outcome results
None listed