anxiety depression
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Above 18 years of age • Fluent in Dutch • Eligible for MRI • Normal or corrected-to-normal vision • Normal uncorrected hearing • Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and comply with the study requirements For patients: • Current or recent (i.e. last year) Axis I diagnosis of anxiety (Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia), PTSD or OCD and/or depression) Major Depressive Disorder, Persistent Depressive Disorder) diagnosis (assessed using the Mini-international Neuropsychiatric Interview)
Exclusion criteria
Exclusion criteria: • Insufficient comprehension of the Dutch language • Abnormal hearing or (uncorrected) vision • Drug or alcohol addiction in the past 6 months • Diagnosis of bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective illness • Current psychosis • Current neurological disorder, past neurological disorder within the last three months • Physical, cognitive, or intellectual impairments interfering with participation, such as deafness, blindness, or sensorimotor handicaps • History of cardiac disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Functional Magnetic Resonance Imaging (fMRI) • Psychophysiological recordings (heart rate, electromyography) • Behavioural measures of avoidance behaviour (choice: approach/avoid) • Self-report questionnaires (treatment outcome, avoidance questionnaire) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Resting state fMRI • Electrodermal activity • Breathing rate • Questionnaires (anxiety symptoms, depressive symptoms, cognitive avoidance, intolerance of uncertainty, motivational systems) | — |
Countries
Netherlands
Outcome results
None listed