Neurodevelopmental Disorder
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: Multiplex (MPX) families will be enrolled when there are at least two diagnosed individuals, one with ASD, and at least one other first or second-order member with epilepsy, ASD, ID or ADHD (age 3 years and older). All unaffected first-degree relatives of an MPX family will be invited to participate as well.
Exclusion criteria
Exclusion criteria: None of the biological parents of the ASD proband is available / willing to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Complete genetic profile of all participants (including rare and common genes). 2) Refined phenoptyping of all participants by means of questionnaires and interviews in terms of: ASD symptoms and traits, Cognitive and neurocognitive level, Developmental level, Somatic comorbidities (clinical epilepsy, allergies, immune disease, gastro-intestinal problems) and Psychiatric comorbidities. A subsample of the participants will be invited for a nested follow-up study with assessment of EEG/ERP, eye-tracking and cognition; for this, we will submit an amendment at due time. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed