Brain infarct or haemorrhage
Conditions
Interventions
The ABI inpatient and outpatient groups will either receive solely conventional
rehabilitation (control group) or conventional rehabilitation with the addition
of training with Koji's Quest (experim
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Minimum age of 18 2. Speaking Dutch or English fluently 3. Acquired brain injury (ABI) diagnosed by a neurologist a. Intracerebral hemorrhage (ICH) b. Cerebral infarction c. Subarachnoid hemorrhage (SAH) d. Transient ischaemic attack (TIA) e. Traumatic brain injury (TBI; e.g. concussion) f. Brain tumor (resection) 4. In the subacute (one day to three weeks) or chronic (more than three weeks) phase post-injury 5. Reported cognitive complaints (in our online questionnaire) see Appendix 2 of C1. Research Protocol
Exclusion criteria
Exclusion criteria: 1. Unable/incapacity to give permission for participation (IC) 2. Unable or unwilling to use a VR headset/computer screen for test administration 3. In the acute phase post-injury (the first 24 hours) 4. Diagnosed with epilepsy 5. Comprehension disorder, such that participants cannot understand instructions 6. Significant adverse symptoms related to cyber sickness measured by the SSQ in the initial session 7. Participation in other studies during the course of this study 8. Those who have such severe physical deficits so that using a controller is not possible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inpatients - Composite score of the neuropsychological tests (NPO) The primary measure of interest in this study is cognitive performance. This will be operationalised through the creation of a neuropsychological composite score from a battery of cognitive tests. We are interested in examining whether a course of cognitive rehabilitation can induce/create treatment effects of cognitive performance. We will compare the neuropsychological composite score before (T1) and after the training procedure (T2). To achieve this aim, the experimental group will undergo conventional rehabilitation with the addition of VR. To ensure that any observed differences are not due to spontaneous recovery or test-retest effects, we will compare changes in cognitive performance (T1 - T2) to an active control group who will take part in conventional rehabilitation only. We are also interested in understanding whether any observed improvements are robust and maintained over a 6-week period (T3). Therefore, we will also investigate whether cognitive performance changes from the post training time point (T2) to the follow up timepoint (T3). Outpatients - CoCo-P Questionnaire Another primary consideration of the current study is to understand whether any cognitive improvement observed in the neuropsychological tests and functional questionnaires also transfers to a treatment effect in cognition, quality of life, and activities of daily life. In order to operationalize this construct, we have chosen the CoCo-P Questionnaire. Performance on the CoCo-P Questionnaire will be examined pre (T1) and post (T2) the training protocol, and once again at the 6- week follow up sessions (T3) to enable us to understand both immediate and more delayed treatment effects, e.g., to observe if improvements are robust and maintained over a 6-week period (T3). To achieve this aim, the experimental group will undergo conventional rehabilitation with the addition of VR. Once again, to ensu | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The difference between inpatient versus outpatient performance in terms of treatment effect. 2. Interaction effects of NPO, questionnaires, medical and demographic factors. | — |
Countries
Netherlands
Outcome results
None listed