Corona Covid-19
Conditions
Interventions
None listed
Sponsors
Zuyderland Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - All patients admitted to the ICU /dept. of Lung diseases of the hospital with COVID-19 related complaints. - Patients were required to have data on clinical chemistry and hematological parameters to calculate the CoLab-score.
Exclusion criteria
Exclusion criteria: - Patients 10* standard deviation (SD)) in one or more of the Colab-values) o hemolytic blood samples
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following parameters will be collected: - PID nr - date of birth (age is not enough, because we need the age at that moment with 2 decimals to run the algorithm) - Gender - Date admission ICU/nursing ward - Date mechanical ventilation/intubation - Date SARS-CoV-2 RT-PCR - Result SARS-CoV-2 RT-PCR - When positive, Ct-value RT-PCR - Date SARS-CoV-2 viability PCR - Result SARS-CoV-2 viability PCR - When positive, Ct-value viability PCR - Date blood test - CRP - Albumin - Bilirubin, total - LDH - Alkaline Phosphatase - GGT - leukocytes - erytrocytes - eosinophilic granulocytes - basophilic granulocytes - Date CoLab linear predictor calculation - result CoLab linear predictor The CoLab linear predictor (outcome), SARS-CoV-2 RT-PCR and viability PCR results. Internal and external verification of the adapted algorithm, to rule out that patients recovering from COVID-19 are infectious. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. What is the development over time of the (adapted) CoLab-score in COVID-19 positive patients in isolation at the ICU/nursing ward of Pulmonary Diseases? 2. After how many days shows the (adapted) CoLab score a normalization in COVID-19 patients in isolation at the ICU/nursing ward? 3. After how many days the SARS-CoV-2 viability-PCR will become negative in comparison with the SARS-CoV-2 RT-PCR? 4. Is the development of the CoLab-score over time associated with the development of multi-organ failure (serial organ failure assessment; SOFA- score) over time in mechanically ventilated COVID-19 patients at the ICU? 5. Is a low CoLab-score over time associated with negative SARS-CoV-2 viability PCR testing in COVID-19 patients? 6. What is the impact (in costs / benefits and stakeholder experiences) of the implementation of the CoLab score in standard practice? | — |
Countries
Netherlands
Outcome results
None listed