Blood-brain barrier leakage as a predictive factor for post-stroke epilepsy

Blood-brain barrier leakage as a predictive factor for post-stroke epilepsy - BBBinPSE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52151

Enrollment

Registered

2020-12-18

Start date

2021-05-25

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsie epilepsy after stroke Post-stroke epilepsy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: A SeLECT score 0-9 or a CAVE score 0-4 Age of >= 18 years

Exclusion criteria

Exclusion criteria: Contra-indications for a gadolinium based contrast agent (known allergy or insufficient kidney function determined by an eGFR

Design outcomes

Primary

Measure	Time frame
To identify potential imaging biomarkers for early identification of patients at risk for PSE, by investigating blood-brain barrier leakage in acute phase and during first stage of rehabilitation. To elucidate the relationship between blood-brain barrier permeability and other microstructural (connectivity, integrity) and microvascular properties (perfusion, diffusivity, blood flow, blood volume) of the brain in PSE patients. Data acquisition at two time points makes it possible to monitor the pathophysiological changes between the primary effects and early recovery.	—

Measure

Time frame

To identify potential imaging biomarkers for early identification of patients at risk for PSE, by investigating blood-brain barrier leakage in acute phase and during first stage of rehabilitation. To elucidate the relationship between blood-brain barrier permeability and other microstructural (connectivity, integrity) and microvascular properties (perfusion, diffusivity, blood flow, blood volume) of the brain in PSE patients. Data acquisition at two time points makes it possible to monitor the pathophysiological changes between the primary effects and early recovery.

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Secondary

Measure	Time frame
To determine the relation between blood-brain barrier integrity and alterations in structural and functional network formation in the brain. Serial MRI measurements allow for the evaluation of spontaneous network reorganization after tissue damage.	—

Countries

Netherlands

Outcome results