fibrillary ocular structures
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Patients with glaucoma, high myopia or exudative AMD • Healthy participants • 18 years of age or older • Willing and able to sign the informed consent, after reading the patient information form • Able to maneuver into the ophthalmic devices (in case of wheelchair-bound type III patients) • OI patients need to be accompanied by a friend or family member during their visit
Exclusion criteria
Exclusion criteria: • Media opacities, like cataract, causing unreliable images with the PS-OCT • Any ocular disease (outside glaucoma/myopia/exudative AMD) with possible influence on ocular fibrillary structures • Recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) quantification of the amount of variability in fibrosis measurements calculated from PS-OCT images; the standard deviation of fibrosis volume measurement needs to be measured within one session in several patients to determine the sample size and expectations of future research to measure fibrosis growth. 2) A change to the scleral retinal ring layer around the optic nerve head in myopia and glaucoma patients when compared to nearly age/sex-matched healthy volunteers. 3) Measuring the orientation of collagen in the peripapillary sclera in OI patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are: Current diagnostics tools (visual acuity, slit-lamp examination/biomicroscopy, fundusphotography, standard OCT, eye pressure, axial measurement) General quality metrics for PS-OCT scans by calculating feature signal-to-noise ratio and the useful signal penetration depth in the sclera for patients and healthy volunteers. | — |
Countries
Netherlands
Outcome results
None listed