Dopaminergic mechanisms of gating working memory, learning, and motivation: A pharmaco-fMRI study

Dopaminergic mechanisms of gating working memory, learning, and motivation: A pharmaco-fMRI study - Dopamine and cognitive function

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52146

Enrollment

Registered

2021-06-22

Start date

2021-10-19

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

distractibility lack of motivation

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Healthy volunteers between 18-45 years of age. - Right-handed

Exclusion criteria

Exclusion criteria: Neuropsychiatric disorders; history of drug abuse; heart problems; metal objects in or around the body (see section 4.3 in the Research Protocol C1 for full list of exclusion criteria).

Design outcomes

Primary

Measure	Time frame
Behaviour on cognitive tasks (working memory, reward learning & perceptual decision making, and effect of motivation on cognitive control), and associated physiological measures: • working memory: BOLD signal (measured with fMRI)	—

Secondary

Measure	Time frame
Our secondary aim is determine how relevant interindividual differences (impulsivity, working memory capacity) may moderate drug effects. For this we will assess the relationship of behavioural performance on computerized tasks (as above) with i) subjective measurements (self-report questionnaires); ii) performance on neuropsychological tests (WM capacity	—

Countries

Netherlands

Outcome results