The effect of arterial oxygen content on mitoPO2 in healthy human volunteers

The effect of arterial oxygen content on mitoPO2 in healthy human volunteers - MitoPO2 and arterial oxygen

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON52136

Enrollment

Registered

2022-02-21

Start date

2022-12-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beademing lack of oxygen mitochondria

Interventions

Hypoxemia (saturation of 85%) and hyperoxemia (up to FiO2 100%)

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age 18-30 years healthy participants: absence of active or chronic disease, not taking medication BMI 18-25kg/m2

Exclusion criteria

Exclusion criteria: Participation in an investigational drug study within 3 months prior to screening Allergy to plaster adhesives History of photo dermatosis or porphyria High altitude exposure in previous 3 months >1500m Active smoking History of cardiovascular disease family history of myocardial infarction with age

Design outcomes

Primary

Measure	Time frame
Difference in mitoPO2 and mitochondrial oxygen consumption at several oxygen saturations.	—

Secondary

Measure	Time frame
1. To determine whether ALA-uptake in the skin can be enhanced by using a dermaroller 2. To determine the effect of hyperoxia and hypoxia on markers of mitochondrial function and their relation to mitoPO2.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)