Oncogene pijn, centrale neuropathische pijn intractable pain severe pain
Conditions
Interventions
Patients will undergo an implantation of an extradural pituitary surface
electrode in the posterior pituitary fossa. The electrode will be attached to a
neurostimulator via which the patient can giv
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: two patient categories are studied, with each their own set of inclusion criteria set one: - Adult patient - In palliative phase of metastatic disease - Inadequately controlled pain with standard care - Karnofsky Performance Score >=50 set two: - Adult patient - Diagnosed with central neuropathic pain - Inadequately controlled pain with standard care
Exclusion criteria
Exclusion criteria: • Not fit for general anesthesia • Pregnancy • Unfavorable local anatomy for PGS, due to a disease process, or anatomical configuration • Clinical signs of posterior pituitary gland disfunction • Recent history of alcohol or drug abuse • Immunodeficiency • Need for anticoagulation therapy that cannot be abrogated for surgery • Cognitive impairments prohibiting full understanding of study and ability to provide informed consent • Not able to adequately communicate in Dutch or English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain, defined as continuous or background pain, measured via a Numeric Rating Scale and on the Brief Pain Inventory, corrected for medication use Patient satisfaction with treatment Treatment safety in terms of side effects | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of analgetic medication Hormone levels Patient-reported outcome measures: pain interference, social role functioning, cognitive functioning | — |
Countries
Netherlands
Outcome results
None listed