impaired glucose tolerance prediabetes
Conditions
Interventions
Twelve weeks of 1100 mg of apple polyphenol supplementation. At the start,
middle and end of the study, several measurements will take place.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Aged from 40 - 70 years • 22.5
Exclusion criteria
Exclusion criteria: • Subject following an overly imbalanced or restrictive diet as per nutritional advice • Concurrent systemic disease and/or laboratory abnormalities considered by investigators to be detrimental for the participants safety or potentially interfering with the study procedures and/or study outcome • Abdominal surgery interfering with gastrointestinal function, upon judgement of the medical doctor, who will decide in-or exclusion based on the surgery applied • Participants who received antibiotics in the 90 days prior to the start of the study • Use of other medication will be reviewed by a medical doctor, who will decide on in- or exclusion based on the drug(s) used • Use of laxatives within 14 days prior to the study • Using medications for gastric or intestinal complaints • Drug use, interfering with any of the outcome parameters of this study; to be decided by the person who is medically responsible for this study • Having donated blood in the 3 months prior to the study • Administration of antioxidant supplements, investigational drugs or participation in any scientific intervention study, which may interfere with this study (to be decided by the principle investigator), in the 14 days prior to the study • History of side effects towards intake of antioxidant supplements • Participants who have a gluten or lactose intolerance • Use of proton pump inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the effect of apple polyphenols supplementation on glucose tolerance. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To determine whether daily supplementation with an antioxidant cocktail at breakfast and dinner for a period of 12 weeks influences the circadian pattern of blood glucose levels. • To assess the effect of a 12-week period of daily dietary antioxidant supplementation of apple polyphenols on fecal SCFA concentrations and fecal microbiota composition. • To identify whether a combination of amino acids and triglycerides can function as early blood metabolic biomarkers that reflect glucose tolerance status of prediabetic individuals. | — |
Countries
Netherlands
Outcome results
None listed