cardiac perfusion heart attack systolic dysfunction
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Aged >= 18 years. • Capable of understanding and signing informed consent. • Stage 1: o scheduled for conventional contrast-enhanced echocardiography • Stage 2: o Admitted to the Erasmus MC Cardiology ward for an elective cardiac procedure • Stage 3: o Admitted to the Erasmus MC Cardiology ward o Planned for cardiac surgery • Stage 4A: o underwent PCI in the past hour; o is recovering in the medium-care unit; o is physiologically stable and awake; o suffered a single-vessel ST-elevated myocardial infarction o still carries an intravenous line; o oral explicit approval by the treating intervention cardiologist to perform a contrast-enhanced echographic study in the medium-care unit for this patient. • Stage 4B: o Was included in stage 4A, at most 6 months before (range: 3 - 6 months) o Is physiologically stable o Has had no serious adverse events or other cardiac complaints/STEMIs in the mean time
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • Patients living abroad or who are not Dutch speaking; • Any contra-indication for contrast media Sonovue (Bracco International bv, Amsterdam), or Luminity (Dutch supplier: LamePro bv, Breda); • Patients with inability to obtain adequate echocardiographic examination; • Pregnant and/or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter of this study is the myocardial perfusion deficit between cardiac segments and/or between the epicardial and the endocardial border, directly after percutaneous coronary intervention, as determined with high-frame rate contrast echocardiography. We expect, based on many studies of post-PCI measurements (e.g., scar tissue on MRI scans; post-mortem histology; preclinical animal testing) that there is local variation in perfusion both between segments, as well as trans-mural. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Establish expectation of feasibility in clinical practice in / nearby the Cath lab, and in the outpatient clinic. • Develop a comparative framework with current standard protocols for perfusion imaging (TIMI score, conventional contrast-enhanced echography) • To explore the added value of high frame-rate echocardiography in patients that have underwent a PCI. • Assess the blood flow in the left-ventricular cavity nearby the wall | — |
Countries
Netherlands
Outcome results
None listed