Non-coeliac wheat sensitivity wheat sensitivity
Conditions
Interventions
Volunteers will each undergo two test days, separated by a wash-out period of
at least 4 weeks. At the test day, volunteers receive either isolated ATIs or
placebo (physiological saline), ingested u
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) No gastrointestinal complaints and/or disease 2) Age between 18-65 years 3) BMI between 20-30 kg/m2
Exclusion criteria
Exclusion criteria: 1) History of severe cardiovascular, respiratory, urogenital, gastrointestinal/hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. 2) Use of medication, including nutritional supplements, except oral contraceptives, within 14 days prior to testing. 3) Administration of investigational drugs or participation in any scientific intervention study, which may interfere with this study (to be decided by the principal investigator), in the 180 days prior to the study. 4) Major abdominal surgery interfering with gastrointestinal function. 5) Pregnancy, lactation. 6) Excessive alcohol consumption, smoking, drug use. 7) Blood donation within 3 months before or after the study period. 8) Plan to lose weight or follow a specific diet within the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal barrier function associated gene expression induced by ATIs. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal barrier function associated protein levels and blood markers Markers of immune activation: gene expression, tissue infiltration of immune cells, quantification immune cell populations and blood markers | — |
Countries
Netherlands
Outcome results
None listed