stress-gerelateerde klachten Stress-related mental health problems
Conditions
Interventions
Participants will be randomly allocated to receive either an EMI that boosts
positive reappraisal (ReApp) or an EMI that boosts reward sensitivity (Imager).
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Participants are healthy students (18-27 years old) who have experienced at least three life events which were each evaluated as burdening. Participants have a total GHQ (i.e. general health questionnaire) score >= 20. Volunteers are proficient in the Dutch language.
Exclusion criteria
Exclusion criteria: The participant currently meets criteria of a relevant psychiatric disorder except for a mild depressive episode (ICD F32.1), tobacco dependence (ICD F12) and substance abuse as established using the Mini-International Neuropsychiatric interview. The participant has met criteria for a relevant psychiatric disorder except for a mild depressive episode (ICD F32.1), tobacco dependence (ICD F12), and a substance abuse in the past 9 months. The participant has ever been diagnosed with a severe mental or organic disorder that affects neurodevelopment due to its pathological mechanism or treatment. The subject*s body mass index is lower than 18 or higher than 27. The participant is not eligible for functional magnetic resonance imaging. The participant reports the use of alcohol 24 hours before the second test baseline test battery. The participant took any psychoactive substances 4 weeks prior to the first or second baseline test battery. The participant is not eligible to wear the Chill+ or eligible for functional MRI. The participant is not free of COVID-19 related symptoms.The participant is currently in psychiatric treatment. The participant receives hormonal treatment other than oral contraceptives and/or takes steroids. The participant has participated in the DynaMOBS study, and/or any study including a fear conditioning and/or stress induction paradigm, and/or any study using an EMI similar to ReApp or Imager. The participant has a full beard.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is dynamic stress resilience as measured with a residuals-based stressors reactivity score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in resilience in relation to the given EMI are associated with biological parameters, psychological questionnaires, neuroimaging, and ecological momentary & physiological assessments. | — |
Countries
Netherlands
Outcome results
None listed