NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology

NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology - NEwTON

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51986

Enrollment

115

Registered

2021-05-28

Start date

2021-07-15

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

boxing dementia Chronic traumatic encephalopathy (CTE) dementia pugulistica

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patient: Repetitive head injury Age 30 + years Symptoms have changed from premorbid functioning Clinical duration of symptoms >12 months At least 1 core feature - Cognitive symptoms - Neurobehavioral dysregulation Controls: - Age 30+ years - No history of participation in organized contact/collision sports, professional military service - No reported neurologic, psychiatric or cognitive disorder or symptoms - No history of clinical significant TBI and/or concussion

Exclusion criteria

Exclusion criteria: - Insufficient knowledge of Dutch language - Not mentally competent to give informed consent For patients: MMSE

Design outcomes

Primary

Measure	Time frame
- Neuropsychological performance - Psychiatric/behavioral symptoms - Neuropsychological and psychiatric/behavioral progress - Determination of potential biomarkers CSF - Collection of MRI data, including DTI. Measurement of cortical atrophy, cavum septum pellucidum, cortical thinning, white matter changes, spatial distribution of magnetic susceptibility (QSM) and resting state cortical activity	—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results