coronary vasculary dysfunction functional impairment of the small vessels of the heart and/or temporary spasm of vessels of the heart
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients referred for a coronary function test because of chronic angina, defined as symptoms of angina at least 2 times a month despite medical therapy for the last 3 months, in whom obstructive coronary artery disease was ruled out by coronary computed tomography angiography or coronary angiography. - Patient is willing and able to provide written informed consent for participation in this study - Patient is willing and able to provide written informed consent for blood withdrawal and storage of blood in the biobank
Exclusion criteria
Exclusion criteria: - Insufficient understanding and communication Dutch language. - No consent of the patient to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is to find out if and which (dynamic) ECG changes can be detected in patients with angina and non-obstructive coronary arteries, by measuring the ECG at home for several days, and how the ECG changes can be detected, by body surface potentials measurement at the hospital before and after exercise. The results of this study will be used to set-up a diagnostic study to investigate if ECG home monitoring has added value in the diagnosis of microvascular angina / vasospastic angina. | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline study parameters including (but not limited to) age, gender, ethnicity, medical history, risk factors and symptoms will be collected and investigated. In addition, with the patient*s consent, clinical care data is collected from the referring centres and information on morbidity and mortality is collected, by means of linkage with national registries. | — |
Countries
Netherlands
Outcome results
None listed