early-stage knee osteoarthritis / knee arthrosis knee osteoarthritis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients (m/f) aged 45-65 years Presence of non-traumatic knee complaints for at least three months NICE guideline diagnosis of clinical knee OA (i.e. aged 45 or over and activity related joint pain and either no morning joint-related stiffness or morning stiffness that lasts no longer than 30 minutes) Average physical activity level of the performed type of activity, which is their primary sport activity, in the last 6 months: o Running: >= 60 minutes running per week o Cycling: >= 120 minutes cycling per week o Tennis: >= 1 hour (match and/or training session) per week o Hiking: >= 1 hike of at least 10km per week
Exclusion criteria
Exclusion criteria: Other pathological conditions that could explain knee complaints like traumatic onset knee complaints, presence of other forms of arthritis (rheumatoid arthritis, psoriatic arthritis), pre-patellar bursitis or patellar tendinitis Onset of knee complaints > 24 months ago Contraindications for MRI No mobile phone or wearable device to track physical activity and unwilling to share tracked physical activity data. Presence of any complaints other than knee OA resulting in physical impairment that will limit the physical activity Unwilling to participate No or insufficient knowledge of Dutch language No access to e-mail Surgery on the affected knee in the last six months Planned surgery on the affected knee in the period of participation Fulfilling the inclusion criteria for more than one of the four physical activities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in structural progression of knee OA between the selected physical activities (running, cycling, tennis, and hiking) after 24 months follow-up, scored using our recently introduced definitions for longitudinal evaluation of OA MRI features. Structural progression of knee OA: scored using recently proposed definitions by our research group for longitudinal evaluation of OA MRI features. All subregional change scores (1 for progression, *1 for improvement and 0 for no change) will be summed over the different MRI Osteoarthritis Knee Score (MOAKS) subregions into an overall measure of change per feature. The summed change scores per feature will consequently be dichotomized into progression versus no progression (change score >= 1 = progression, change score | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Differences in clinical progression of knee OA expressed as change on sub-scales of KOOS and patient nominated activity pain score between the selected physical activities (running, cycling, tennis, and hiking) after 24 months follow-up. 2. Association between GPS-based individual activity profiles and increased risk of knee OA progression 3. Interaction between inflammation (including inflammatory markers IL-6, CRP, proteomics and questionnaire data) and genetics and physical activity on the progression of clinical and structural knee OA 4. Interaction between physical activity and known risk factors for knee OA, on the progression of knee OA 5. Role of the microbiome on the progression of knee OA in different types of physical activities. 6. Interaction between daily activities and the progression of knee OA in different types of physical activities. | — |
Countries
Netherlands
Contacts
Public ContactJ.W. Voort
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed