Cancer Dysplasia
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All adult patients (>=18 y/o) with a diagnosis of IBD undergoing surveillance colonoscopies can be enrolled after giving written informed consent to enrollment.
Exclusion criteria
Exclusion criteria: - Ongoing malignancy (other than CRC).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of mucosal immune populations and the microbiome in biopsies taken from patients with aIBD with and without dysplasia, and with and without colitis-associated cancer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of patients* genotype (including whole genome methylome and transcriptome) associated with mucosal immunotype and microbiome in relationship to the presence of dysplasia/cancer. Determination of luminal microbiome (in biopsies and faeces) associated with mucosal immunotype and microbiome in relationship to the presence of dysplasia/cancer Determination of serum cytokines and chemokines associated with mucosal immunotype and microbiome in relationship to the presence of dysplasia/cancer | — |
Countries
Netherlands
Outcome results
None listed