tissues and organs
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age >= 18 years • Primary intra-axial brain tumour of any type or secondary brain tumour (brain metastases) of any solid tumour • Signed and dated written informed consent form prior to any study-specific procedures • WHO performance status of 0 or 1
Exclusion criteria
Exclusion criteria: • Glucose- and/or FDG-infusion related exclusion criteria: o Uncontrolled Diabetes Mellitus type 1 or 2 (requiring fast-acting insulin) o Uncontrolled tonic-clonic seizures (>1 per month despite anti-epileptic treatment) • Not being able to undergo contrast enhanced MR scans or [18F]FDG-PET exam (in line with local protocol13): o Pacemaker, mechanic heart valve, blood vessel prosthetic, stent or coil incompatible with MR scanning o Metal in eyes (splinters, from surgery), ears (hearing aid) or on the body where it cannot be removed (e.g. insulin pump, piercings) o Dental prosthesis with magnetic system o Breastfeeding o Pregnancy o Claustrophobia o Known anaphylactic reaction to [18F]FDG or gadolinium-based contrast agents • Severe blood iron deficiency (with haemoglobin concentration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GlucoCEST signal of pre-, during and post-glucose bolus injection values, standardized uptake value (SUV), signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR), tumour volume, tumour perfusion | — |
Countries
Netherlands
Outcome results
None listed