Immune responses to an in vivo challenge model using the tuberculin skin test in patients with mycobacterial infections

Immune responses to an in vivo challenge model using the tuberculin skin test in patients with mycobacterial infections - MyCoS-TST

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51809

Enrollment

Registered

2023-01-09

Start date

2023-03-03

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mycobacterial infection

Interventions

None listed

Eligibility

Age

16 Years to 64 Years

Inclusion criteria

Inclusion criteria: Mycobacterial infection

Exclusion criteria

Exclusion criteria: - Known type 1 hypersensitivity to tuberculin PPD RT23 SSI or one of the excipients; - History of a severe local reaction to tuberculin PPD RT23 SSI or similar products; - Hypersensitivity to lidocaine or local anaesthetics of the amide type or one of the excipients; - History of keloid scarring.

Design outcomes

Primary

Measure	Time frame
Transcriptional profiling of skin biopsies to determine molecular changes in immune responses at the site of TST or saline injection.	—

Secondary

Measure	Time frame
Immunohistopathology of skin biopsies to determine molecular changes in immune responses at the site of TST or saline injection.	—

Countries

Netherlands

Outcome results