Neural Substrate for Emotional Memory Schemas in Individuals with Early Life Adversity

Neural Substrate for Emotional Memory Schemas in Individuals with Early Life Adversity - Neural substrate for emotional schemas

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51804

Enrollment

115

Registered

2022-09-21

Start date

2022-11-22

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early life adversity emotional memory emotional schemas due to childhood experiences

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Normal or corrected-to-normal vision Normal uncorrected or corrected-to-normal hearing Willingness and ability to understand nature and content of the study Ability to participate and comply with study requirements Fluent in Dutch (>= B1 level)

Exclusion criteria

Exclusion criteria: History of or current or previous neurological or psychiatric disorders (except depression), or other relevant medical history, cognitive impairments History of or current brain surgery or epilepsy Pregnancy MRI incompatibility (unremovable metal parts in upper body [plates, screws, serre-fines, dental plates (pontics), metal splinters, piercings or medicinal plasters), active implant [e.g. Pacemaker, neuro stimulator, insulin pump and/or hearing aid], head operation, epilepsy, claustrophobia).

Design outcomes

Primary

Measure	Time frame
The main study parameter is neural mechanism underlying the relationship between early-life-adversity and emotional schema memory effect. Therefore, a within-subject design with an fMRI measurement is conducted to investigate emotional schema memory effect and its neural correlates. Here we define emotional schema memory effect as: when a negative schema is activated by music mood induction procedures, the participants will have enhanced memory performance for negative stimuli at the behavioural level. At the neural level, we will analyze the encoding related activity particularly subsequent memory effect (SME) and spatial pattern (representational similarity) in the medial prefrontal cortex (mPFC) and hippocampus.	—

Measure

Time frame

The main study parameter is neural mechanism underlying the relationship between early-life-adversity and emotional schema memory effect. Therefore, a within-subject design with an fMRI measurement is conducted to investigate emotional schema memory effect and its neural correlates. Here we define emotional schema memory effect as: when a negative schema is activated by music mood induction procedures, the participants will have enhanced memory performance for negative stimuli at the behavioural level. At the neural level, we will analyze the encoding related activity particularly subsequent memory effect (SME) and spatial pattern (representational similarity) in the medial prefrontal cortex (mPFC) and hippocampus.

—

Secondary

Measure	Time frame
Secondary study parameters are the measurements for attention and emotion bias (skin conductance recodings, self reports and eye-tracking data), which will control the specificity of the bias. It might be possible that memory bias effects are caused by biases in attention and emotion, therefore it is important for future use of the results to properly control by these parameters.	—

Countries

Netherlands

Outcome results