Respiratory microbiome and clinical data analysis for the prediction of acute exacerbations in COPD

Respiratory microbiome and clinical data analysis for the prediction of acute exacerbations in COPD - REDALERT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51796

Enrollment

150

Registered

2022-04-26

Start date

2023-12-27

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic lung disease with persistent narrowing of the airways Chronic Obstructive Pulmonary Disease (COPD)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >= 18 years Written informed consent Physician-confirmed diagnosis of COPD (spirometry) (FEV1

Exclusion criteria

Exclusion criteria: Inability to understand the nature, scope, and possible consequences of the study Life expectancy of less than 12 months Newly diagnosed active pulmonary tuberculosis within the last 12 months Unstable cardiopulmonary or metabolic co-morbidities Macrolide maintenance treatment

Design outcomes

Primary

Measure	Time frame
Accuracy of risk assessment for the prediction of acute exacerbations of COPD based on microbiological and clinical analyses	—

Secondary

Measure	Time frame
- Composition of the respiratory microbiota in patients with COPD and relation to exacerbation history and clinical parameters - Compositional clustering of respiratory microbiota in relation to disease phenotype - Research changes/shifts in the respiratory microbiota in patients with COPD in the stable phase, during exacerbation and recovery	—

Countries

Netherlands

Outcome results