Towards novel BIOmarkers to diagnose SEPsis on the emergency room

Towards novel BIOmarkers to diagnose SEPsis on the emergency room - The BIOSEP Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51785

Enrollment

3120

Registered

2022-03-30

Start date

2022-10-25

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

nvt

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Suspected infections with MEWS score of 2 or higher

Exclusion criteria

Exclusion criteria: No informed consent provided

Design outcomes

Primary

Measure	Time frame
• SOFA and MEWS score collected on and during admission; • Sepsis at (ED and/or hospital and/or ICU) admission; • Final diagnosis for hospitalization; • Assessment of the host immune response by Raman spectroscopy, transcriptomics, proteomics, lipidomics, metabolomics, and gut microbiota.	—

Secondary

Measure	Time frame
• Duration of hospital stay; • Duration of ICU stay; • Hospital mortality; • ICU mortality; • 28-day mortality; • 60-day mortality; • 1-year mortality; • Sequelae of sepsis up to 60-days post admission (decreased executive functions, weakness, fatigue, mood, etc.); • All-cause readmissions in the first year after discharge.	—

Countries

Netherlands

Contacts

Public ContactA. Kolodyazhna

Amsterdam UMC

biosep@amsterdamumc.nl0205669111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Feb 3, 2026