Burkholderia pseudomallei infection Melioidosis melioidosis infection
Conditions
Interventions
n.a.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: adult patient with one of the following comorbidities: - Type II Diabetes - HIV-1 - Renal failure (eGFR < 30 or on dialysis) - Liver failure (Child-Pugh score A,B or C) - Thalassaemia (with and without iron overload) - COPD (2 < GOLD > 3/4).ORadult patients with confirmed B.pseudomallei infection
Exclusion criteria
Exclusion criteria: Patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will outline the differences in macrophage function, specifically phagocytosis, bacterial killing, and cytokine response, and B cell function (antibody responses) in those at higher risk of acquisition due to underlying comorbidities in melioidosis, healthy controls and patients with B.pseudomallei infeciton. | — |
Secondary
| Measure | Time frame |
|---|---|
| To delineate the underlying processes, such as gene expression and immuno-metabolic profiles, to understand altered macrophage function. Additionnaly, to identify B.pseudomallei specific BCT from single cells to define anigen specificity, reactivity and functionality | — |
Countries
Netherlands
Contacts
Public ContactW.J. Wiersinga
Amsterdam UMC
Outcome results
None listed