obesity insulin resistance overweight
Conditions
Interventions
The participants will first undergo a low caloric diet (LCD, ~900kcal) for 8
weeks. Participants that loss at least 8% of weight will be randomized (with
stratification for age and sex) in a weight
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Overweight/obese (BMI >= 28 kg/m2
Exclusion criteria
Exclusion criteria: - diabetes mellitus - gastroenterological diseases or major abdominal surgery (allowed i.e.: appendectomy, cholecystectomy) - lactose intolerance and other digestive disorders - cardiovascular disease, cancer, liver or kidney malfunction (determined based on ALAT and creatinine levels, respectively) - disease with a life expectancy shorter than 5 years - abuse of products (alcohol consumption > 15 units/week, or any drugs) - excessive nicotine use defined as >20 cigarettes per day - plans to lose weight or follow a hypocaloric diet - regular supplement of pre- or probiotic products - intensive exercise more than three hours a week - Use of any medication that influences glucose or fat metabolism, like lipidlowering-drugs (e.g. PPAR γ or PPARa (fibrates) agonists), glucose-lowering agents (including allsulfonylureas, biguanides, a-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin), inflammation (e.g. anti-inflammatory or immunosuppressive drugs) and anti-oxidants; - use of laxation products in the last three months or during the study period- Suikerziekte heeft; - Pregnancy and lactation -vegan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in body weight | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body composition, glucose metabolism, insulin sensitivity and metabolic health by evaluation the following parameters: - BMI, waist and hip corcumference and body composition (DEXA scan) - cirulating metabolites, hormones and inflammatory markers - adipose tissue gene/protein expression - faecal and circulating SCFA - faecal microbiota composition | — |
Countries
Netherlands
Outcome results
None listed