Acute immunotoxicological effects of traffic-related micro- and nanoplastics in urban air.

Acute immunotoxicological effects of traffic-related micro- and nanoplastics in urban air. - PETE: micro- and nanoPlastic Exposure and immuno-Toxicological Effects

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51750

Enrollment

Registered

2022-06-17

Start date

2022-07-18

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immunotoxicological health

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy young adults, aged 18 - 45 years, living in the neighborhood of the Utrecht Science Parc.

Exclusion criteria

Exclusion criteria: smoking, respiratory inflammation (i.e. COPD or asthma), cardiovascular disease, or the use of anti-inflammatory/respiratory/cardiovascular medication.

Design outcomes

Primary

Measure	Time frame
The main study endpoints are MNP levels in blood and changes in inflammatory markers (i.e. blood leukocytes, cytokines) and antioxidant defence levels in blood.	—

Secondary

Measure	Time frame
Secondary endpoints include lung function (FEV1, PEF), changes in inflammatory markers in saliva and respiratory symptoms.	—

Countries

Netherlands

Outcome results