dysmenorrhoe Endometroisis painfull menstruation
Conditions
Interventions
The anti-inflammatory diet that is advised in this intervention is very similar
to the Dutch Dietary Guidelines 2015 (20). However, the anti-inflammatory diet
is stricter in terms of (red) meat inta
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients are: confirmed endometriosis by ultrasound, MRI or surgery; inclusion criteria for all participants are: age 18-45 years; ability to understand the explanation about the dietary intervention, motivation not to change using food supplements (if applicable), use of hormonal contraception (combined oral contraception, or progestogens). Motivation to collect menstrual effluent in stop week
Exclusion criteria
Exclusion criteria: Exclusion criteria are: pregnancy, eating disorders; Crohn*s disease, colitis ulcerosa, self-reported coeliac disease, self-reported lactose intolerance, short bowel syndrome, chronic inflammatory disease, veganistic diet, unwillingness to adhere to the dietary intervention, BMI below 18 or above 30, smoking, use of immunosuppressive medication, score on FFQ > 120, NRS average score below 4 during the last month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: The main study parameters are the change in HRQoL (as measured by the Endometriosis Health Profile (EHP)-30 and Short Form (SF)-36, as well as a general rating) and pain symptoms (as measured by a Numerical Rating Scale (NRS)). | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate the effect of an anti-inflammatory diet on characteristics of inflammation in serum and menstruum samples as well as the effect on the gut and vaginal microbiome. | — |
Countries
Netherlands
Outcome results
None listed