Parkinson Parkinson's disease
Conditions
Interventions
All participants will sleep in whole-body head-up tilt (HUTS) in three angles
for two weeks (6°, 12° and 18° for the intervention group
1°, 6° and 12° for
control groups). The 1° condition in the control group is considered the
control intervention. and each angle is preceded by a week ofof the HUTS
sleeping position is The interve
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Orthostatic hypotension defined as a systolic BP decrease of >=20 mmHg, or a diastolic decrease of >=10 mmHg, within 3 min after changing from a supine to standing position OR mean standing BP of = 30 mmHg is required. 2. Orthostatic intolerance: direct complants (dizziness, tunnel- or blurry vision etc.) and/or inirect signs (falls or freezing episodes that relate to postual challenge) 3. Supine hypertension defined as a systolic BP of >=140 mmHg, and/or diastolic of >=90 mmHg, after 5 min of supine rest. 4. Idiopathic PD. 5. Ability to walk (with or without a walking aid). 6. Stable medication regimens for orthostatic hypotension and supine hypertension.
Exclusion criteria
Exclusion criteria: Cognitively unable to follow instructions or to fill out questionnaires as judged by the researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overnight blood pressure (BP) from 24-hour ABPM between patients and controls | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include: daily supine blood pressure, orthostatic blood pressure, orthostatic tolerance (complaints of orthostatic hypotension), nocturia, PD motor- and non-motor symptoms, physical activity during the day, falls and subjective comfort of HUTS. | — |
Countries
Netherlands
Outcome results
None listed