Familial hypercholesterolemia identification through innovative use of existing laboratory data

Familial hypercholesterolemia identification through innovative use of existing laboratory data - PELICAN

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51701

Enrollment

600

Registered

2022-10-31

Start date

2022-07-01

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Patients with severe hypercholesterolemia (LDL-cholesterol level above 99,5th percentile for age and sex).

Exclusion criteria

Exclusion criteria: Three failed blood withdrawal attempts.

Design outcomes

Primary

Measure	Time frame
The main outcome in this study will be prevalence of genetically confirmed FH in a preselected population of individuals with severe hypercholesterolemia (diagnostic yield). DNA genotyping in this study will be performed using a customized Illumina GSA v3 array.	—

Secondary

Measure	Time frame
The secundary study parameter will be the diagnostic yield of existing clinical criteria for genetically confirmed FH.	—

Countries

Netherlands

Outcome results