metabolic syndrome
Conditions
Interventions
Subject will participate in both arms of this cross-over study in which they
oblige to both a daily time-restricted eating (TRE) protocol and a control
protocol for each two weeks, separated by a fo
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: the at-risk group: • Body mass index (BMI) 30 to 43 kg/m2) • HOMA-IR index of >= 2.5 (measured as fasting insulin (pmol/L) x fasting glucose (mmol/L)) / 135) • At least 3 out of 5 NCEP metabolic syndrome criteria Healthy group • Body mass index (BMI) 18 to 25 kg/m2, • Waist circumference between 79 cm and 94 cm, • HOMA-IR index
Exclusion criteria
Exclusion criteria: - Excessive weight loss of >10% in the last months; - Use of any medication - Pregnant, trying to get pregnant or breast feeding at inclusion; - Irregular menstrual cycle; - Hormonal replacement therapy. - Cholecystectomy; - Untreated GI disease/abnormal bowel habits; - A history of cardiovascular event (MI or pacemaker implantation)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to determine the direct effects of long-term intermittent fasting on immune cell populations in the blood, combined with analyses of systemic metabolic fitness and inflammatory activation of leukocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are to determine: - Shifts in immune cell populations and inflammatory activation of leukocytes. - The effect of IF on the transcriptional and epigenetic repertoire of monocytes. - The fitness of monocyte responses by analysing their response to an inflammatory metabolic challenge (i.e., mixed meal challenge). - The effect of IF on metabolic parameters such as body weight, resting energy expenditure, insulin sensitivity, glucose tolerance and postprandial bile acid and FGF-19 responses. - The effect of IF on gut microbiota. | — |
Countries
Netherlands
Outcome results
None listed