Functional MRI and Doppler ultrasound of living kidney donors and recipients: a longitudinal trajectory from donor to recipient

Functional MRI and Doppler ultrasound of living kidney donors and recipients: a longitudinal trajectory from donor to recipient - FUNTRAC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51682

Enrollment

Registered

2022-03-31

Start date

2024-11-01

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nier Transplantatie Transplant failure Transplant function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Be part of a matched pair of living kidney donors and recipients; Transplantation and follow-up consult performed at UMCG; 18-75 years old.

Exclusion criteria

Exclusion criteria: Subjects aged

Design outcomes

Primary

Measure	Time frame
Functional MRI (fMRI) (P) ASL: % Renal Blood Flow (ml/min/100g) DWI-IVIM: Molecular diffusion (Dslow, mm2/s), Microperfusion (Dfast, mm2/s), Fraction of microperfusion (ffast, %), Apparent diffusion coefficient (ADC, mm2/s) DKI: Diffusional Kurtosis (DK), Diffusion coefficient (mm2/s) DTI: Fractional Anisotropy (FA), Trace (tr), Mean diffusivity (MD, mm2/s) BOLD: Relaxation rate (R2, s-1) TMRE: shear wave speed (m/s), viscosity (rad) Doppler Ultrasound (DUS) *% Resistive Index (RI) Grayscale Median (GSM) Shear wave elastography (SWE, kPa) Microbubble (CEUS) Contrast Enhanced Ultrasound (Peak, TP, AUC, MTT) Corticomedullary Differentiation (CMD) Volume (ml)	—

Measure

Time frame

Functional MRI (fMRI) (P) ASL: *% Renal Blood Flow (ml/min/100g) DWI-IVIM: Molecular diffusion (Dslow, mm2/s), Microperfusion (Dfast, mm2/s), Fraction of microperfusion (ffast, %), Apparent diffusion coefficient (ADC, mm2/s) DKI: Diffusional Kurtosis (DK), Diffusion coefficient (mm2/s) DTI: Fractional Anisotropy (FA), Trace (tr), Mean diffusivity (MD, mm2/s) BOLD: Relaxation rate (R2*, s-1) TMRE: shear wave speed (m/s), viscosity (rad) Doppler Ultrasound (DUS) *% Resistive Index (RI) Grayscale Median (GSM) Shear wave elastography (SWE, kPa) Microbubble (CEUS) Contrast Enhanced Ultrasound (Peak, TP, AUC, MTT) Corticomedullary Differentiation (CMD) Volume (ml)

—

Secondary

Measure	Time frame
The measured and/or estimated glomerular filtration rate. Kidney biopsy histology (when available/clinically indicated). Prognostic/Follow up parameters (Duration of admission, postoperative complications, surgical reintervention, delayed graft function (DGF), graft failure, postoperative dialysis, renal function at 1 week, 3 and 6 months and 1 year post-transplant, patient survival).	—

Countries

Netherlands

Outcome results